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Old 06-05-2007, 04:11 PM   #6
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
Wow, you are quite a veteran. I can tell you're a fighter!

I'll give you my 2 cents (which is worth probably way less than that!) but, maybe could you clarify something for me. You say they are calling the kidney tumor a new primary? So is it a kidney cancer not a metastasis from the breast cancer? That may impact the treatment decisions if you are trying to do adjuvant chemo for a kidney lesion - although many of the treatments for renal cell cancers are the same as for bc.

I agree with what the others have said re the A/C and the cardiac toxicity. The risk of this with Herceptin after A/C is higher than if you did not have the A/C. And not to throw yet another wrinkle in, but have you considered T/H weekly instead of every 3 weeks? This uses a lower dose, and is supposed to be better tolerated and just as effective.

It sounds like you would also consider continuing the hormonal treatment, if this is a new primary and still er+
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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