Is her2 breast cancer hereditary

[sabpri]

I am always the one to bust the "norms", but I had 2 Tumors, one was ER/PR+ and Her2 Neg, the other was Triple Negative, but contained a Subpopulation that was Her2+, Amplified. No one really knew what bucket to put that one in, but it did have Her2+ in it. I also tested positive for BRCA2, which I was TOTALLY shocked over. No one in my family has had BC. My mom and her sister never have, and neither has my grandmas or any of their 8 sisters! We were shocked when my mom tested BRCA2+ (she opted to test when I tested + and then they tested my dad thinking it was him since he had cancer on his side of the family). When his came back negative, we knew it was probably her. She is in her 60's and has never had any cancer.

I am very scared for my little girls, but they are only 3 and 5, so I pray to God things will be much more advanced (even a cure!) by the time they grow up. At least they will be "on alert" and not unprepared like me.

I did have ooph in March of this year due to hormone+ and BRCA status.

Natalie

[rinaina]

Thanks Soccermom for the lead. Was able to find quite a few at both hospitals I am dealing with. I appreciate your help.

[Soccermom]

Dear Rinaina,
I am so glad that I could help! If you'd like to do some reading on the subject of BRCA mutations please go to ...www.facingourrisk.org
FORCE has a reading room where one has access to much information from accredited sources.
Let me know how it goes for you.CGC's (Certified Genetic Counselors), are in my estimation,some of the kindest folks. They are the true masters of explaining the implications of testing positive/inconclusive and/or negative for the BRCA mutations.

Its a rough road but like most here you have probably already been through a lot.
Let me know if there is anything else I can help with...and you can help clue me in on Her2!



Dear ((((Natalie))))))))),
I understand your fears
regarding your children. Dr Andrew Tutt (a Bristish researcher/Dr.) is presently conducting trials in the U.K. on a BRCA "vaccine". He spoke at the FORCE conference which was held in Feb. of this year. If you want to you see his presentation via webcast at the FORCE website.
I pray everyday for a cure for ALL of us!

Marcia


Marcia

[MJo]

sabpri:
Your post interested me. I had five maternal great aunts who died of breast cancer in their 40s. The doctor told me I probably don't have the BRCA gene because cancer skipped my mother's generation and I'm the first of my generation to get it. But your experience tells me that might not be so. It's hard to find family history due to my mother and aunt's faulty memories (they are in their 80s) and the fear and denial that still lingers about this disease. I know my great aunts had radical mastectomies back in the 1950s and early 1960s but the cancer spread quickly anyway. Sounds like Her2. I believe that other hereditary genes besides BRCA will be found relating to breast cancer. Possibly there is a hereditary factor in Her 2. We just don't know yet.

[Soccermom]

Dear MJo,
I only have a minute but wanted to expalin something re: BRCA. IF you have a mutation in the family you have a 50% chance of inheriting it. If for some reason both parents have a BRCA mutation that increases the odds to 75% (if they are different mutations). The BRCA genetic mutations follow
"autosomal dominant" patern of inheritance which means it does not "skip" a generation. Not everyone that carries a mutation of one of the BRCA genes goes on to develope cancer. In fact studies revealed that the incidence of cancer in BRCA+ men and women showed a marked increase in occurence in those born after 1950.
. The theory
is that because we have added so many pollutants, (fertilizer,pesticides etc) to our environment a SECOND incident to the already mutated gene "triggers /
allows" the cancer to develope.
I am a little rusty on my stats, but I think you get the gist of it.

Hope this was helpful,
Marcia