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I have the same regimine and I stopped Herceptin after the first loading dose for 3 1/2 weeks while my heart recovered from 45% to 52% ejection fraction. My onc's cutoff for me was 50%. He explained that Herceptin blocks the hearts ability to heal itself, so if I were to continue Herceptin at 45%, I'd be at risk because my heart would not recover beyond 45%. But a few weeks off Herceptin and I resumed the protocol because the ECHO showed my EF recovered to 52%.
We simply will extend the end date of Herceptin, but I will get all the doses. This has not been a problem with anyone I have discussed it with both patients and oncs. It happens to many patients.
I would not be concerned. Seems to happen from time to time.
pel50
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