Age at Diagnosis Poll Ponderings

[RobinP]

Please excuse me for not having the source available, but I recall reading that the estrogen receptor migrates out of the nucleus to reside in the cytoplasm in the estrogen negative state. So the receptor is still there, it just dosen't drive the cellular activity. Apparently, once her2 is switched on, the possiblity of this migration out of the nucleus is much more common than not since most her2+ are estrogen negative.

By the way folks, just a last minute thought more on this topic. I wonder if her2 can lay dormant in the body for years and then be triggered. I know that most her2s relapse the first few years after dx. so it seems unlikely that this would happen often, if at all.