Effect Of Herceptin On Primary Tumour

[heblaj01]

From many posts on this forum it appears that Hercetin alone (or in combination with Navelbine) has dramatic beneficial effects on metastases.
But what about the primary tumour if it has not been surgically removed?
How soon does it start to shrink?
Can it be eradicated & if not can its size be sufficiently reduced (say 1cm or less) to allow surgical excision under local anesthesia (as opposed to general anesthesia which is risky in the case of elderly patients with cardiovascular problems)?
Has anyone experienced treatment along these lines?