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From HER+ back to ER+: how to diagnostic?
A study has shown that a fraction of HER+ patients treated with Herceptin become resistant & they return to their original ER+ status & are then treated again with anti estrogen drugs such as Tamoxifen or Letrozole sometimes over several years.
How is the change of status detected? Is there a non invasive way to do the diagnostic? How often should this be checked?
(I am aware that in an other study readministering Herceptin to patients declared resistant shows renewed efficacy in some of them. My above questions are not related to the latter cases).
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