New thread--how many long-lived Stage IVs are hormone receptor positive?

[Lani]

I would like to start another thread inquiring of those Long-Lived Stage IVs what their hormone receptor status(ER AND PR) is and, if ER positive, how long they have been/were on antihormonal therapy, and what kind

I have heard bantered around that the ER receptor pathway may be the origin of the resistance that develops to Herceptin treatment.

If this is so, would the cancer be expected to return when antihormonals are stopped--which, I suppose, they never do in Stage IVs, but perhaps some of you had to stop them because of side effects...

I hope this isn't too much of an imposition for our long-lived "legends"

I doubt Genentech nor any of the researchers at MD Anderson, Dana Farber, Mayo, etc has looked at this (it is hard to pool data between institutions without formal clinical trials) and drug companies are often slow to do their post-marketing research as it doesn't directly and quickly affect their bottomline...

Thanks to you all,
Lani