Pertuzumab and Herceptin Trail

[RobinP]

Is anyone at her2support on the new clinical trail for Herceptin and Pertuzumab that opened in Dec. 2005? As I understand it, the reason why some people MAY progress while they are on Herceptin is due to other infidel erbB family members, her1, and her3 heterodimering. Herceptin is only specific for her2. However, Pertuzumab is another monoclonal antibody, similar to Herceptin, that has the unique ability to attach to her1,3. Hopefully, results will be seen with the Pertuzumab, Herceptin combination to further increase DFS and OS. If results are seen with this combination in metastatic trails, it is likely that adjuvant trails will also run with this pair for a better efficacy than Herceptin alone. What would really make an interesting trail would be Lapatinib, Herceptin and Pertuzumab. As lapatinib would target her1 and her2. Herceptin would target her2 and Pertuzumab her1,2,3. That's it, just shut down the whole erbB pathway.