Contralateral/Bilateral Tumor while on Herceptin?

My 35 yr old wife has developed a contralateral ER+/PR+ HER2+ tumor in her remaining breast while on Herceptin and being in chemo induced menopause.

Has anyone developed a contralateral/bilateral HER+ tumor while on Herceptin?

Her oncologist seems stumped as to what the next approach should be.



Here is a summary of events:
5/12/04- Original Diagnosis Core Biopsy - Right Breast Infiltrating Ductal Carcinoma, ER+/PR+, HER2 3+, Estimated at least 2.3cm.

5/24/04- Lumpectomy - Actual tumor size 6.5 cm, margins not clear, 14/15 nodes positive, Bloom-Richardson 7/9, grade 2. Bone & CT Scans clear.

6/12/04 Started Chemo- 4 Rounds AC (Dose Dense) + 4 Rounds Taxotere (Dose Dense)
Two Staff infections in right breast. One was MRSA.

9/04 BRAC testing negative / MRI of Left Breast Clear

10/21/04 Mastectomy Right Breast- found 2 multicentric IDC’s 2 mm & 1 mm Margins Clear.

12/23/04 Completed Chest, Neck & Axillary Radiation

1/05 Started 1yr Herceptin regimen and 6 rounds of Navelbine

7/21/05- had small lump in left breast removed.
Infiltrating Ductal Carcinoma, ER+/PR+, HER2+, Size 2.8 cm
Bloom-Richardson 7-8/9, grade 2-3, Extensive Lymphovascular Invasion present. Positive Margins. Has In-Situ component present, which means it is a new independent tumor.

8/8/05- Full PET Scan was clear other than hot area in left breast.

8/10/05- Left Breast Mastectomy with sentinel node biopsy. Waiting on path Results.