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I have had brain mets since dx in Sept '02, 14 months ago.
Since then, I have had three Stereotactic Radiosurgeries treating a total of ten tumors. I have consistently refused Whole Brain Radiation.
My last SRS procedure was done on Dec. 22, treating four of my eight current tumors. The remaining four are each nearing the 1cm mark in size.
My med onc is in the process of getting me a referral for the CyberKnife procedure. We are lucky to have this available here, one in a multi midwest state area. It is similar to the SRS or GK but has NO SCREWED ON headframe. Which is the worst of these procedures in my experience.
If I can not get this done, my next step is to try Xeloda. I am currently on Temodar. Have finished just two cycles so don't know to what effect yet.
Here is what I have found on Xeloda for brain mets:
Vol. 1, 1139-1145, October 2002 Molecular Cancer Therapeutics
© 2002 American Association for Cancer Research
A recent study reported the effective use of Capecitabine (Xeloda) for brain metastases originating from breast cancer (7). The partial response (shown by decreased lesion size and improved mental performance) was particularly noteworthy because previous hormonal treatment, whole brain irradiation, and systemic chemotherapy, including treatment with 5-FU, proved ineffective. In addition to providing a potentially effective treatment for brain metastases, this study demonstrated that: (a) tumor resistance to 5-FU does not preclude effective treatment with Capecitabine; and (B) Capecitabine can reach therapeutic concentrations in brain tumor tissues.
This was not a trial, but a study. Not a LOT of info out there about it. But, under the circumstances, I am more than willing to give it a try. My med onc is with me on this, warning that I may not see any response, but willing to give it a shot too.
In my opionion, I would do ANYTHING to avoid the WBRT. With subsequent side effects and eternity on Decadron, the drug from hell.
hugs,
pattyz
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