trial?

Hi all,

The more time that I spend on this board the more that I appreciate the imortance of trials. As a result, I would like to hear your thoughts and recommendations on the following...
My wife is stage IIIa with, according to IHC her2 +2-+3 (awaiting FISH confirmation). The onc put her on a dose dense regimen (every 2 weeks rather than 3) which appears to have ruled her out of most trials. She has just completed 4AC and is scheduled for 4 taxol, to be followed by weekly herceptin and radiation. Her onc has not brought up any trials or vaccines and feels comfortable with the plan. I, however, am less comfortable for several reasons...
* by enrolling in a trial she could contribute
* it seems that she could take herceptin after a vaccine trial, but not the other way around.
That being said, I am concerned about...
* a recurrance if she defers the herceptin and the vaccine doesn't work for her
* she does not tend to react well to drugs (she had to be hospiatlized for 2 of her 4 AC treatments). As a result I would be very concerned with her going into a trial to determine proper dosages.

Since my wife prefers not to be exposed to any information yet I cannot ask her what she would like to do but I would like to know your thoughts as well as any recommendations of trials.
Thank you and best wishes...Eric