rising tumor markers on navelbine-

Thanks for your responses. In response to a couple of your comments:
Neulasta - I don't take that, but do have to give myself 3 shots of neupogen each week after chemo for my wbc.
I was on taxotere/herceptin for 6 months last year. That dimished the bone mets a lot, but didn't clear them completely. But when I started taxotere my ca2729 started to go down immediately, that's why I'm concerned that my markers are up even in the beginning of navelbine. I am having more pain in my rib area this week too where I know the main bone mets are. Now I don't know if it's totally physical or if my worry/emotions are feeding in to that pain too.