herceptin loading dose

I, too, was getting it weekly for my mets. The loading dose took longer AND was a larger amount than the regular weekly dose. They also want to slow down the infusion to watch for any reaction to herceptin the first time. My nurse did not sit with me, but my husband did and the nurse checked about every 5 minutes or had someone else look in on me.
All the best for your wife's successful battle!