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Decided to stay on Teresa...
Argh!what a week! Three differ radiologists look at the scans and I get three different views...
After much thought and discussion with those I trust I am staying on TDM1 and rescanning in three weeks.
I have not progressed according to trial criteria. The target lesions have grown 15%. So they are saying stable. My private oncologist feels result is borderline when entire view of lungs is taken into account. 2/3 say no new disease. The other issue is scan was on a different machine with higher resolution. Trial oncologist is also saying lung mets on TDM1 appear to respond slower and sometimes flare a little before reduction and that perhaps I haven't had full benefit of the drug yet. The radiologist I trust the most has looked at the 6 lesions that have changed the most and they are around the 20- 25% mark but there are numerous unchanged or just marginally changed lesions.
So...I don't want to jump off this horse that is so low toxic until I have to so we are ridding TDM1 a little longer with full understanding that it may not be doing much for me but maybe it is keeping me relatively stable. It seems lung mets are difficult to measure too.
I'm in the chair waiting and happy with my decision.
Here's to me simply being a slow responder rather than a non responder!
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Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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