Herceptin stopped working

[Emy]

Stage 4 mets to liver, and bone did well on Herceptin for 7 months stopped working...Now on Herceptin and Tykerb 1500 daily, I had no reaction at all...oncologist says I need to stay on for 3 months even though not working......stopped working...Tumor markers rising from 40 to 86 in 6 weeks..PET scan showed everything more than doubled in size...Will TDMM1 work? ..How do I get in trials?