What's especially nice about this, but not mentioned is that these two drugs appear to be available:
http://en.wikipedia.org/wiki/Decitabine
It is a
hypomethylating agent.
[1][2] It hypomethylates DNA by inhibiting
DNA methyltransferase. It functions in a similar manner to
azacitidine, although decitabine can only be incorporated into DNA strands while azacitidine can be incorporated into both DNA and RNA chains.
Azacitidine (
INN) or
5-azacytidine, sold under the trade name
Vidaza, is a chemical
analogue of
cytidine, a
nucleoside present in
DNA and
RNA. Azacitidine and its deoxy derivative,
decitabine (also known as 5-aza-2′deoxycytidine), are used in the treatment of
myelodysplastic syndrome
It seems like these two might be usable as a treatment themselves or as chemo "primers", given before more standard treatment allowing avoidance of overlapping toxicities.
I'd be very curious about this preceeding low dose metronomic chemo and/or vaccines/immune approaches.
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