That's interesting info about Her2 testing. But what part of the site says
only patients receiving "real" chemo have benefit? I found
this which is not so clearcut:
Quote:
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We are treating more patients with combination therapy (DCA + 1 or 2 other drugs) and feel more confident now that DCA works better in combination with other agents than by itself over a prolonged time period.
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I believe the
glioma cases were monotherapy.
Regarding the interference with chemos, even within platinums, seems there are studies on both sides of the issue.
http://www.springerlink.com/content/a570v5561073g130/
Quote:
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multicellular spheroidal growth, as observed in the H835 cell line and pulmonary tumourlets, seems to increase chemoresistance markedly. The activity of carboplatin and JM118 is significantly and specifically increased in combination with the apoptosis sensitiser DCA that promotes mitochondrial respiration over aerobic glycolysis. In summary, among the novel platinum drugs satraplatin has the potential for treatment of lung carcinoids and DCA potentiates the cytotoxicity of selected platinum drugs.
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