Need help from TDM 1 girls

[michka]

Dear all
I am getting ready in case Herceptin and Navelbine doesnt' work. I don't want to go through other toxic chemos before trying TDM1. I am suffering too much from neuropathic problems;
But in my case it is complicated. Herceptin and chemo never worked for me. I was ER+90% PR+20% at diagnosis 4,5 years ago then in December after laparoscopy ER+20% and PR0 then in March after resection 70%ER+ and 0%PR-???? Here are my questions:
1) How often is TDM1 given? and for how long? For ever?
2) I am american but live in France. Does anyone know of a European trial?
3) I do not want a TDM1 trial against Taxol and Herceptin. I had that in neoadjuvant setting and it did not work a all
If necessary I can live in the States for some time although I will be broke. But who cares.
Any European friends with some ideas?
Is there anyplace I can call at Genetech to discuss this?
I am sorry for these questions because it is clear in my head but the English is not as precise as I would like it to.
Thank you for your help.
Michka