Conflicting Her2 Status -- please advise

[samdobbs]

I'm posting for my wife Liddy stats below.

We just received results from OnctotypeDX showing
Her2 Negative! Overall RS 24

Previously FISH was +ive (2.8) after equivocal IHC

Anyone encountered this situation? Any pointers to
reliability/accuracy of FISH vs. Oncotype?

Thanks in advance

Sam

--
49 years old, premenopausal, IDC and DCIS present, no family history
12/28/10 Excised tumor 1.5x1.0x0.9 cm, clean margins
Grade: Histologic 2, Nuclear 2, Mitotic 1, Overall grade 1(2+2+1=5)
Sentinel Nodes: 0/3,
ER+ (60%), PR+ (86%)
HER2+ Eqv by IHC, Positive by FISH (2.8), Negative by Oncotye (10.0)
Ki-67 = 3+ intensity, 17% of cells
Overall oncotype recurrence score 24