PAX2 & AIB-1 in Taxmoxifen Resistance
I've read that for Her2+/ER+ patients, Tamoxifen hormonal therapy doesn't work very well if the patients also have low levels of the PAX2 protein and/or high levels of the protein AIB-1. I believe the AIB-1 somehow interferes with proper functioning of the PAX2-Her2 receptor pathway. That raises questions for me:
1.) Are some doctors testing Her2+/ER+ patients for their levels of PAX2 and AIB-1 proteins, when deciding which hormonal therapy to use (AIs or SERMs)?
2.) Are there ways (drugs or CAMs) that can help raise the PAX2 or knock down the AIB-1 levels?
bird
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Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.
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