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OPEN ACCESS: A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats [Nutrition & Metabolism]
Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate
rotein on promotion and early progression of breast tissue carcinomas. Mammary tumors were induced by N-methyl-N-nitrosourea (MNU) at 52 d of age. Post-induction, animals were assigned to consume either a low protein high carbohydrate diet (LP; 15% and 60% of energy, respectively) or a moderate protein reduced carbohydrate diet (MP; 35% and 40% of energy, respectively) for 10 wk. Animals were fed 3 meals/day to mimic human absorption and metabolism patterns. The rate of palpable tumor incidence was reduced in MP relative to LP (12.9 1.4 %/wk vs. 18.2 1.3 %/wk). At 3 wk, post-prandial serum insulin was larger in the LP relative to MP (+136.4 33.1 pmol/L vs. +38.1 23.4 pmol/L), while at 10 wk there was a trend for post-prandial IGF-I to be increased in MP (P = 0.055). There were no differences in tumor latency, tumor surface area, or cumulative tumor mass between diet groups. The present study provides evidence that reducing the dietary carbohydrate
rotein ratio attenuates the development of mammary tumors. These findings are consistent with reduced post-prandial insulin release potentially diminishing the proliferative environment required for breast cancer tumors to progress.
http://www.nutritionandmetabolism.com/content/7/1/1
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