Ovarian Suppresion for Pre-Menopausal Women - What is the Latest?
Hi everyone,
I had my original biopsied tissue retested for its ER status and I found out that I am 30 % ER+ (2+) instead of 5 %. My oncologist had already put me on Tamoxifen as soon as I finished my radiation treatment, and I'm glad that she did so.
My question is whether I should consider adding Zoladex shots to my treatment. I finished chemo at the end of July, had my surgery in August, started radiation in September, and had a period in October (hasn't returned yet on the Tamoxifen). I'm also on Herceptin and I've had 7 infusions so far (one before my surgery).
Can anyone point me to studies/papers that have looked at the combination of Tamoxifen/ovarian suppression vs. Tamoxifen alone for pre-menopausal women (and especially HER-2+ ones?) My oncologist mentioned the SOFT trial but that is still ongoing.
What is the latest recommendation on ovarian suppression with Taxomifen?
Thanks!!!
Marcia (bejuce)
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ER+ (30%)/PR-/HER-2+, stage 3
Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin
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