Neratinib Trial

[TSund]

Ruth has been asked if she would like to participate in the Neratinib trial. (pre-metastatic) She is really, really torn about it. She is so ready to be DONE. She is on schedule to move to visits with the onc every 6 months unless she does this trial.

As I understand it, this drug does have a plus that Herceptin does/did not, in that it is thought to cross the blood/brain barrier. It also is given orally. It does have a high incidence of diarreha, something she is not thrilled about. She is however thinking that participating in a trial is a way to "give back", and possibly give herself another dose of met prevention. I don't know if the severity of diarreha is similar to that which she experienced with TCH.

If this drug has the potential to make as much difference as Herceptin (something I have no idea of) it seems like it could be a huge counter-punch, and possbily more useful than the AI she will move to from Tamoxifen in 6 months time. Of course, she could be among the 50% that receives the placebo, however if she partcipates and does get the diarreha, it's a pretty sure bet that she's receiving the Neratinib.

Any wisdom would be appreciated.

Thanks

Terri