AACR 2008: ABSTRACT #LB-95: Evidence for increased metastatic dissemination after core needle biopsy of breast cancer in an in vivo model of human tumour metastasis
[American Association for Cancer Research]
The standard of care in the investigation of clinically or mammographically detected breast cancer is a core needle biopsy. Several studies have demonstrated tumor cell displacement along needle tracks and into draining lymph nodes following core needle biopsies. The clinical consequence of this observation remains the subject of ongoing debate. We hypothesized that the biological tumor response to core needle biopsies would result in increased tumor growth, vascular migration and distant spread of viable malignant cells. To test our hypothesis we used MDA-MB435 cells grown on the chorio-allantoic membrane (CAM) of 8-day-old chick embryos. Our results demonstrated that core needle biopsy significantly increased the overall metastatic burden in a number of distant organs [Fig 1]. Additionally, evidence was seen for a biopsy induced trophic shift in the pattern of metastatic dissemination observed in the biopsied chick embryos when compared to the pattern of metastases observed in non-biopsied tumors [Fig 2]. Our experimental results support clinical reports of tumor cell displacement into lymph nodes following core needle biopsies. Additionally, these findings suggest that the change in pattern of increase in metastasis observed in biopsied animals is related, at least in part, to a biological alteration (trophic change) in the breast cancer cells and or tumor microenvironment resulting from the core needle biopsy, rather than being entirely a consequence of mechanical displacement of cells into the surrounding vasculature.
http://www.docguide.com/news/content...D0060C157(less technical coverage)
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