Hi folks,
quick question...
What testing method gives a Her2 result in the double digits? The only ones that I am ware of are FISH and IHC neither of which,to my knowledge, ranges to the double digits. In Barbs talk w Dr Pegram he spoke of ranges in the doiuble digits, so I am confused?
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Thanks for any clarification,
Marcia
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There are 2 types of tests available to determine HER2 status: Fluorescence In Situ Hybridization (FISH) and ImmunoHistoChemistry (IHC). - A FISH test checks to see whether or not the cancer cells have a normal number of HER2 genes. Using a special microscope the pathologist looks at cancer cells to see how many HER2 genes there are compared with some other normal genes
- If there are 2 or more HER2 genes for each normal gene in the cells (that is, if the ratio is =2.0) the tumor is HER2+
- An IHC test measures how much HER2 protein there is on the surface of the cancer cells. The test is scored on a scale of 0 to 3+
- A patient who has a tumor with a score of 3+ is considered to have HER2+ breast cancer
- The National Comprehensive Cancer Network guidelines recommend that a tumor with a score of 2+ should be retested with the FISH test to determine whether the tumor is HER2+
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