Meta Analysis: Anthracyclines only helped her2-positive patients

[Christine MH-UK]

I know that Slamon has suggested this, but Italian researchers performing a meta-analysis of 5,000 patients have also just found that only her2 positive benefit:

http://www.nlm.nih.gov/medlineplus/n...ory_59375.html

Ok, it might be topoIIa, but given how harmful anthracyclines are, can oncologists really continue to use them in good faith on her2-negative, topoIIa negative patients?