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John,
I agree with you. Use WBR only as a last resort as its side effects are debilitating. I might also suggest talking with either Dr. Nancy Lin or Dr. Eric Winer, both at Dana Farber. They have extensive experience with CNS tumors are are currently doing research with Tykerb, a drug that also crosses the BBB in combination with Gamma Knife.
I am hoping that PattyZ will also answer your post as she has a long history of treating brain mets with Gamma Knife and various chemos.
WBR is a serious decision and I applaud you for doing the research before making your decision.
Regards
Joe
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