Why Herceptin and not Tykerb?

[Donna]

Good Morning Amazing Group,

I was able to do the interview in San Francisco that was posted here a week ago. It was financed by Genentech - and I am still not sure what they were after - but they paid me for it :-)

After the interview, because of one of the questions, I started to wonder why Herpectin is firstline treatment instead of Tykerb. The way I understand it Tykerb, is actually protective of the heart muscle - and since it works inside the cell instead of at receptor sites, wouldn't this just be more effective with less chance of heart damage - better all the way 'round? Anyone?

Thanks - have a great day!

Donna