change of rx for brain mets

[Emmay]

Just wanted to let everyone know that my sister has changed medications; she had been on temodar/sorafenib since Feb. '07, and while it worked well for the 7 months she was on it, the side effects for her(severe loss of appetite and diarrhea) caused a swift and steady weight loss that was difficult to reverse. The MRI in early Sept. showed slight flaring around a few treated areas, and it was hard to determine if mets were growing or if it was necrosis.

So her breast cancer oncologist and neuro-oncologist decided to switch her to Tykerb(Lapatinib)/Xeloda, which she started on 9/24 -- so far so good. Her Oct.5th MRI showed no further enhancement from Sept.MRI.

I've seen a couple of posts that said that oncologists had said not to take Folic Acid(in many multivitamins) when on Tykerb/Xeloda -- why is that?

Thanks.
Emmay