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Original Stage I's with high KI-67 that progressed?
My onc has always been concered because of my high KI-67 (35%). I wonder why I didn't get Herceptin if he was so concerned????
In light of the meta-analysis coming out at ASCO..."Ki-67 is present in all proliferating cells and has attracted scientists' interest as a marker of proliferation. It has also featured in several 'proliferation signatures' identified using genetic microarrays.
In the study overall, patients with a Ki-67-positive tumor had a 93% increased risk of relapse and a 95% increased risk of death, compared with Ki-67-negative patients."
I would like to know if there are any of you out there that originally began as Stage I and progressed or recurred?
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Diag. Oct. 2004 age 54 left breast
Stage 1 grade 3; 6mm IDC; unknown amount of DCIS
with comedo necrosis; node neg.
Nottingham Grade 7/9
ER 91% PR 62%; Her2 3.6 by ICH; KI-67 35%
Nov 2004 Lumpectomy; SNB failed so had
full axillary clearance;
Dec 2004 2nd lumpy for clean DCIS margins.
Jan/Feb 2005 4 A/C dose dense;
33 rads finished 6/2005;
Began 5 years Arimidex in 6/2005
No Herceptin
9/2007 Quit Arimidex due to severe side effects.
NED
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