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Old 06-01-2007, 05:29 AM   #1
Sheila
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Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
Failed Xeloda...now what

After 1 year of fairly good response, Xeloda has stopped working on me...I was taken off 2 weeks ago....it was a combo of worsening side effects and no shrinkage of neck nodes....so now it is on to Abraxane....my onc. wants the Xeloda to be out of my system totally (the side effects) before adding the Abraxane to my Herceptin. She is not ready to use Tykerb yet as the Herceptin is keeping things contained to the neck nodes. I am disapointed as Xeloda has been easy...hoping the Abraxane will do the trick, or at least keep me stable. She is planning on doing the Abarane every 3 weeks with the Herceptin, even though news from San Antonio said weekly was as good if not better. She said she has not seen this in her patients, that the better response is every 3 weeks. So just wondering from all you Abaxane Divas out there, what to expect as far as side effects....to me, preparation is important. I am hoping my veins hold out, I have been through 4 years of treatment without a port, but my veins are scarring so that may be next. This news and change is coming at a tiome where I feel emotionally and physically exhausted...my best friend is still hanging on but barely there, little or no response. I still go to be with her every day if possible, I know the end is near, but I am still not prepared to let her go. Are we ever?
Thank you all for all your prayers for her...my hope now is that she can go peacefully, watching her slip away slowly has taken a toll.
Again, thanks for your prayers and any advice you can give me on Abraxane...hair loss, nausea, energy level....you are the best resource!!!!!!!!
__________________
"Be kinder than necessary, for everyone you meet
is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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