Exercise and IGF-1 and her2??????

[Donna]

Hi Amazing Group,

I was just reading an article in Newsweek about how aerobic exercise sends out IGF-1 through the bloodstream and it passes the blood brain barrier. That sent out a red flag to me because I seemed to remember that IGF-1 is one of the chemicals suspected to cause Herceptin resistance. When I looked it up in PubMed, they do say this, but they list it as IGF-1 and also IGF-1-R - saying it does in fact contribute to Herceptin resistance.

My question is this: EVERY single thing I have read about cancer says that exercise is the single most important non-medicinal thing you can do to help combat this disease - BUT - if exercise produces IGF-1, are we actually doing more harm than good? Any chemistry savvy members out there know the answer to this?

Thanks - and have a great day!

Donna