Chemo options for brain mets after CyberKnife

[Emmay]

My sister(age 49) is being treated with CyberKnife every 3 months or so as new brain mets appear, usually 2-3 each time, and she's had 6 or more sessions now. She's already had Whole Brain Radiation(11/04) and two craniotomies(10/04 and 5/04). Herceptin has been keeping the rest of her body clear. She feels well and looks well, and her neuro-oncologist is suggesting she try 1 or more chemo agents to try to arrest the mets.

Temodar has been suggested (I know it's been successful for Pattyz for 18 months- yay Patty!!), and Sorafenib (just approved 3-4 months ago for renal cancer) possibly with the Temodar. Other options are Xeloda and/or Carboplatin. Anyone have any experience with any of these for Her2 bc brain mets - Temodar, Sorafenib, Xeloda, Carboplatin? Was it effective, and what were side effects? I know each woman can respond differently, but I'd love to know the experience of women in this group before meeting with her neuro-oncologist on Monday. Sincere thanks for your help.