Does vitamin A inhibit PI3K/Akt?

[Lani]

to be confusing! ie, is it a long-term result of the chemo, a side effect of the antihormonal or a side effect of the herceptin (or just from age and menopause?)



There are two types of vitamin A toxicity, one caused by taking too much vitamin A over a short period of time (acute form) and one that occurs when the excess of the vitamin is present over a longer period (chronic hypervitaminosis A).

In an infant, the suddenly intake of too much vitamin A may cause a bulging fontanelle ("soft spot" on the head) and symptoms resembling those of a brain tumor. This group of symptoms is called "pseudotumor cerebri" and it includes a bulging fontanelle, papilledema (swelling of the optic disc), and double vision. Vomiting and drowsiness are common.

The symptoms in adults are less specific. Headache, visual changes, and impaired consciousness suggestive of pseudotumor cerebri may occur. Other symptoms can include nausea, vomiting, dizziness, and blurry vision.

Chronic vitamin A toxicity develops after taking excessive doses of the substance for extended periods. Bone pain and swelling of the bones is common, often associated with high levels of calcium in the blood. Other symptoms include hair loss, high cholesterol, liver damage, and vision problems. Symptoms are often subtle and may include fatigue, malaise, and nausea.

In children, hypervitaminosis A can cause craniotabes (abnormal softening of the skull bones). Irritability, decreased appetite, itchy skin, and poor weight gain are common. There may be skin changes with seborrhea (extremely oily skin and hair) and cracking at the corners of the mouth.

Increased intracranial pressure is seen in both acute and chronic forms.