Paclitaxel and Her2-neu
Hello Everyone,
Since I have always gotten a straight and informed answer from this site I thought I would ask the following:
I was reading an abstract of an article (Diindolylmethane (DIM) and Paclitaxel Act Synergistically to Promot apoptosis in HER2/Neu Human Breast Cancer Cells, Jan 2006, Journal of Surgery) and came across a reference to the resistance of HER2-neu tumours to chemotherapy. As an aside, the article noted that HER2-neu overexpression confers resistance to paclitaxel. Unfortunately I could not access the full text of the article. Has anyone heard of any studies looking at the resistance of HER2-neu tumours to paclitaxel or the other taxanes?
Keep well,
Carina
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Carina
Toronto, Canada
DX: 12Dec05, Stage IIIa, invasive ductal carcinoma, extra-nodal extension, ER/PR+, HER-2neu 3+, FISH: 7.8
Chemo: AC + T completed 8Sept06, and Herceptin started started 7Jul06 (Herceptin temp. stopped due to allergy)
Hormonal Treatment: 9Oct06 (Arimadex)
Radiation: To start 10Oct06 (5 weeks)
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