Lapatinib/Xeloda dosing
My wife finally got started in the trial today. We are both very hopeful that this trial is the cocktail that succeeds in beating Maryann's cancer.
Cycle is 21 days, Her dose is:
*Lapatinib 1250 mg once/day, d 1-21
*Xeloda in the morning 2000mg, d 1-14
*Xeloda in the evening 1500mg (12 hrs between xeloda doses), d 1-14
In her previous cocktail she took 1500 mg xeloda d 1-14 w/ navelbine and herceptin. That's a big difference but I guess w/o the second chemo agent more than double the dose is appropriate??
Are other folks in lapatinib/xeloda trial taking similar xeloda doses and following similar schedule?
For those computing based on volume, she is 5'7" and 135 lbs
I sent an email directly to Paul to see what he thinks.
Note: Reposted this here (from clinical trail forums) at the suggestion of Lolly. (Thanx)
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Maryann & Ken
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Stage IV, Her2/Neu 3+++, Er & Pr positive,
Primary mets to brain/CSF, bones & lymphs
DX: 2/01, DCIS Rt one, Neoadjuvant chemo, MRM 7/01
Rads to chest, neck, lower spine, pelvis
WBR & cyberknife
Numerous chemo/hormonal cocktails along the way
10/11/06: Started Trial of Lapatinib/Xeloda, after 2 cycles it is declared a failure for us.
11/24/06: Now starting rads to upper spine then IT herceptin
12/07: Took a turn for the worse and entered hospice. Enjoyed remaining time with family and friends feasting on cookies and sushi.
4/11/07: Peacefully passed on. Maryann will be missed by all.
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