recycling used chemos

[rosie]

I am running out of options for my lung mets. We are kind of scraping the bottom of the barrel. I keep asking various oncs about reusing chemos that worked so well before and I keep getting the stock answer which is that if you progressed on a certain chemo, it won't work again.
But if I think about it, some of these chemos are from 4 years ago, and if I have had other chemos since then, is it possible that these might have wiped out those particular resistant cells? What is the downside in trying other than it won't work?
Does anyone have any stories about reused chemos working? Any stories about abraxane or taxol working after a year on taxotere?
I don't have much left to go for.

Anybody know anything about topotecan?

Any ideas welcome.
Rosie