May be just an issue for advanced cancers after becoming resistant to estrogen blocking...
but I think there is some research looking at upregulated androgen receptor activity in resistant BC.
The good news is that a promising phase III prostate cancer driug Abiraterone Acetate, may be helpful to breast cancer:
LINK
Quote:
Scientists have long known that prostate cancer growth, survival and invasion are fueled by the male hormone testosterone. In cases of advanced, metastatic prostate cancer, physicians routinely prescribe ADT to stop production of testosterone and cut off the “fuel” for this cancer that affects more than 16 million men worldwide. However, during the course of treatment, many men become resistant to current androgen deprivation treatments and their disease recurs. Abiraterone has been shown to be effective in treating hormone-resistant or hormone-refractory cases. It blocks the formation of testosterone by inhibiting CYP17A1, an enzyme involved in the formation of testosterone that can occur at the site of metastatic tumor lesions.
“The data on Abiraterone is exciting and we hope to see final FDA approval soon,” said Jonathan W. Simons, MD, president and CEO of PCF. “Clinicians will have a powerful new tool to stem the progression of prostate cancer and extend patients’ lives. We are also encouraged that Phase I/II clinical trials evaluating Abiraterone acetate in advanced breast cancer patients are also underway, emphasizing how discoveries in one area of cancer research can provide benefits in others.”
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With Mom and Dad both suffering hormonal cancers, I'm definitely watching this one.
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