Neratinib Trial
Ruth has been asked if she would like to participate in the Neratinib trial. (pre-metastatic) She is really, really torn about it. She is so ready to be DONE. She is on schedule to move to visits with the onc every 6 months unless she does this trial.
As I understand it, this drug does have a plus that Herceptin does/did not, in that it is thought to cross the blood/brain barrier. It also is given orally. It does have a high incidence of diarreha, something she is not thrilled about. She is however thinking that participating in a trial is a way to "give back", and possibly give herself another dose of met prevention. I don't know if the severity of diarreha is similar to that which she experienced with TCH.
If this drug has the potential to make as much difference as Herceptin (something I have no idea of) it seems like it could be a huge counter-punch, and possbily more useful than the AI she will move to from Tamoxifen in 6 months time. Of course, she could be among the 50% that receives the placebo, however if she partcipates and does get the diarreha, it's a pretty sure bet that she's receiving the Neratinib.
Any wisdom would be appreciated.
Thanks
Terri
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
Last edited by TSund; 10-04-2009 at 02:46 PM..
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