Does vitamin A inhibit PI3K/Akt?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15608670&dopt=Abstract
Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85-p110 heterodimerization
I do not understand the possible implications of this research paper.
Does it mean that vitamin A (once converted into retinol in tissues) could inhibit PI3K/Akt & thus, among other things, reverse resistance to Herceptin?
Can someone shed some light?
I also noticed an article on high levels of retinol associated with lower risk of liver cancer.
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