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Old 12-04-2008, 08:31 AM   #1
Jean
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Your 2 cents worth...

Posting this article here for open discussion.

"Delays in Radiation"...
http://www.medicalnewstoday.com/articles/131382.php

I found this article to be very interesting since this has been a point of interest to me. While I realize the urgency in starting chemo treatment and it is the first treatment that begins, to be followed with radiation, I have been wondering for a long time if those with early stage disease would be served better to be treated with radiation first (especially now since there are new shorter radiation treatments lasting only days) instead of weeks.

The theory being that you attack any cells that may be left behind immediately....at the bed of the tumor. While at SABS last year I saw a film on a new radiation treatment that was performed in the OR right after the surgeon removes the tumor and treatment is applied before the surgeon closes the lumpectomy...very interesting.

My thoughts on this are - since the patient is Stage 1
node neg. maybe radiation should be applied first to offer a complete procedure then go forward with chemo? Note this would only apply in early breast cancer patients...

I can only speak for myself, when I was first dx. and I began to make appointments for my radiation portion of treatment I was met with delays...and the dr. assured me that a couple of weeks would NOT matter. I did not buy it then - (3 yrs ago) it made no sense to me. I pushed and pushed and did get my rad treatment 30 days after surgery....strange that my situation is....I did not have chemo/herception until much later....becasue at the time all onc. would not treat me since I was stage 1 with a small tumor...

Maybe the future for early stage patients is faster treatment with the new methods shorter treatments of radiation to be followed with chemo/herceptin or maybe just herceptin.....Dr. Slamon and I, and my onc. here on the East have discussed this a few times, and they are
keeping records about my "different case"....

Yes, I know sisters, I am weird...
Your input and thoughts ....?

Kind Regards,
jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006

Last edited by Jean; 12-05-2008 at 01:08 AM..
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Old 12-05-2008, 09:15 PM   #2
Jackie07
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Have you ever thought of Jean as being weird? I doubt it.

Bringing this up for everyone to 'toss the coin' (She wanted our 2 'cents'.
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7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
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Old 12-05-2008, 09:31 PM   #3
hutchibk
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Jean, you, weird? Ummmm.... LOL - if smart is weird, then I suppose so ~

I was interested when I saw this on the news yesterday... as I chose NOT to do radiation when first dx'ed.

Then, I noticed that a very important aspect of the story was that it highlighted "older women, over 65" as being the group they were referring to... just FYI.
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NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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Old 12-05-2008, 09:57 PM   #4
Jean
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Hi Brenda,
I realize the study group was in older women - I am still curious to the effects of having radiation ASAP upon healing from surgery (30 days min.) now going forward with the new shorter treatments and then to be followed by chemo/herceptin...or just herceptin?

Wondering if this could be a new approach?
I would consider that younger women would have higher risk factors being pre menopausal and therefore,
any delay in treatment should be questioned. I have heard dr. saying up to 3 months for rad treatment.

Also still wondering if the new shorter rad treatments should be applied first.

Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 12-05-2008, 10:06 PM   #5
Jackie07
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I've read from signatures that some members were having radiation first to shrink the tumor before surgery. Since there are post surgery problems involved (like my fluid (swelling)problem in the lumpectomy site), I wonder if everyone should have radiation first before surgery to cut down the recurrence.
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe
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Old 12-05-2008, 10:13 PM   #6
Jean
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Hmmm that is an interesting tought Jackie,
but I think that the benefit of radiation is to mop up the area afer surgery, but in the case of a larger tumor radiation is used to shrink it.

The study was interesting in that it is showing time is an important issue.

jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 12-05-2008, 10:29 PM   #7
Jackie07
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Sorry about the misinformation. I was thinking about the presurgery chemo (neoadjuvent)to shrink the tumor size. It might not be good to 'burn' the tissue before 'slashing' it.
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe

Last edited by Jackie07; 12-05-2008 at 10:47 PM..
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Old 12-06-2008, 04:22 AM   #8
Mary Anne in TX
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I have never understood why they would wait to do the radiation later if the purpose is to kill any stray, closeby cells left from surgery. It made more sense to me to do the radiation first, even if they had to start chemo midway.
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Old 12-06-2008, 07:01 AM   #9
tricia keegan
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I also think it makes far more sense to have rads first asap after surgery and then go on to chemo. I wonder why they don't??? I assume there must be a reason to do it this way.
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Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
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Old 12-06-2008, 09:23 AM   #10
CLTann
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Postponing treatment for cancer, whichever is the method, is not medically and scientifically defendable. It is pure self serving lie to fit the doctor's schedule. The doctor ought to be sued and sanctioned. The patient's life, to the doctor, is another routine piece of merchandize. I bet he would not take the same view if the patient is him or herself.
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Stage 1 dx Sept 05
ER/PR positive HER2 +++ Grade 3
Invasive carcinoma 1 cm, no node involvement
Mastec Sept 05
Annual scans all negative, Oct 06
Postmenopause. Arimidex only since Sept 06, bone or muscle ache after 3 month
Off Arimidex, change to Femara 1/12-07, ache stopped
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Old 12-06-2008, 04:05 PM   #11
ElaineM
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Wink Your 2 cents worth...

It is quite possible that there is no normal or no standard way of treating patients. Each person's situation is different. Each person might need something a little different than the last person or the next person.
There are so called "standards" of treatment, but even they change from time to time depending on the combined experiences of scientists and doctors with patients. Maybe they should call those "standards"
"guidelines" instead.
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Old 12-08-2008, 09:48 AM   #12
schoolteacher
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Jean,

I started radiation one month after my surgery, so maybe this was a good idea. I started the adjuvant chem almost a month after radiation.

Thank you Jean for posting this article. It has helped me feel a better about my treatment plan.

Amelia
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Old 12-08-2008, 11:35 AM   #13
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Early stage radiation

I was an early stage also, however the surgeon thought radiation would be part of my tx., but when discussed at weekly board, they went with chemo. Even though I did not get 100% clear margins on one of my tumors near the chest wall. (had 4 small individual primaries)
I have always wondered if not having the radiation would make a difference?

Well wishes, to all,
Murph
Feb/07 39 yrs dx IDC (4 seperate tumors, all Her2 +++)
AC/Taxol
Herceptin 1 yr
oopho--followed with Femara
Feb/08 tissue expanders (unhappy with them, looking into changing them Feb/09)
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