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Old 11-06-2006, 02:02 PM   #1
dawn
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Location: Newfoundland, Canada
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Her2Nu Testing

I have a question. Does anyone know what a LSAB Procedure is? I just received my reports from when I was tested for Her2 and it said 10% LSAB Procedure used. I couldn't find anything in the report for FISH or any other test. Any light you guys can shed on this situation would help. They used the same test for my ER+ and PR+.
Dawn
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Dawn

Mar 2006Stage IIIA, Her2/Neu 3+++, Er & Pr positive, 8 of 18 pos 03/14/06: Mastectomy 04/19/06 started Chemo adriamycin, chlophosphamide, taxotere 25 rads
Nov 1, 06: 3 years Tamoxifen, Herceptin (1yr)
Jan 2009 Femara mets to bone aromasin and aredia
June2009: Full Histerectomy
2/22/2010 6 spots in liver 2 mm-10 mm: switched to xeloda and Herceptin will continue with Aredia J
Scan February 2011 new onc, switch to abraxane
April 2011 NED clear organs, 3 spots on bone scar tissue.
Scans August 2mm spot on liver and lungs. now on to tykerb/xeloda
Dec 2011 scans nothing on lungs, liver down to 1 2 mm spot. j
une 2012 another spot on liver on to cisplatin/gemzar.


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Old 11-06-2006, 02:17 PM   #2
tousled1
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Dawn,

The LSAB is just the actual kit that is used in the HER2 test.



<FONT color=#000080>LSAB®, LSAB®2 and LSAB®+<SPAN lang=EN-GB style="FONT-SIZE: 12pt; mso-bidi-font-size: 10.0pt"> (labelled streptavidin-biotin) kits are visualization kits based on the sequential application of biotinylated link antibody and streptavidin labelled with alkaline phosphatase (AP) or peroxidase (HRP). The high sensitivity of this technique allows use of low concentrations of primary antibody. A wide range of carefully matched, prediluted primary antibodies and negative controls for use with the LSAB® and LSAB®2 kits (N-series antibodies) are available from DAKOCytomation .
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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