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05-25-2010, 05:11 PM
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#1
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Senior Member
Join Date: Oct 2005
Location: Saratoga Springs New York
Posts: 136
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navelbine/herceptin
I've been on Adiramycin since September 09. It stopped working and have progession in my liver, spine,right arm and left collar bone. I am going back on Herceptin which I haven't been on in a few years. I will also be on Navelbine which I have never been on. Any info or input on Navelbine/Herceptin 3 weeks on 1 week off would be appreciated. I haven't posted much lately but I lurk often. Thanks for listening. Sally
__________________
Dx March 2004 HER2+ er/pr+ 8/16 + lymphnodes mets to the liver Stage IV / 6 cycles of TCH and 33 rads . NED Continued Herceptin 3 years w/ Femara. Tumor markers start to rise in Jan of 2007 and swiched to Tamoxifen. August of 2007 found more mets to liver and lymphnodes outside of liver. Went on Tykerb/Xeleoda--spots on liver gone found large mass between intestines. March 2008 started TCH. Stopped Carboplatin due to allergy. Still on Taxotere and Herceptin. Nov 2008 mass is gone. 3 new spot on liver and one on spine. Radiation on spine. tykerb/gemzar for liver mets. PET in April 09 showed shrinkage still a little activity, continue tykerb/gemzar until Aug 09. PET showed new spot on my spine more on my liver and a bunch of enlarged lymphnodes in upper chest. Start Adriamycin Sep 09. more radiation on spine . April 2010- Still on Adriamycin 3wks on 1 wk off and zometa every 28 days. PET -May 2010 showed progression. Starting Herceptin/Navelbine on June '10
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05-26-2010, 03:42 AM
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#2
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Senior Member
Join Date: Sep 2005
Location: MN
Posts: 731
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Re: navelbine/herceptin
I had great success on navelbine/herceptin combo a few years ago. I was on it for a year. I had the same schedule: 3 weeks on, 1 off. It was pretty tolerable, I felt good, sometimes slight nausea the day after infusion but mild. The only issue I had on it was my wbc were always low. I had to give myself neupogen shots for 3 days after each infusion. Once I learned that trick it was very easy and I didn't mind it at all. When I quit navelbine after 1 year I was able to maintain on herceptin only for another 6 months.
I was on navelbine again in this last year. Unfortunately it didn't work as well for me the 2nd time around so I'm not on a different combo.
__________________
Pam
6/01 IBC er+ her2+stage IIIb; mastecomy
7/01 AC, taxol; radiation
2/02 tamoxifen
9/02 stage IV bone mets femara
1/03 taxotere/herceptin/aredia
6/03 herceptin, aredia & faslodex
1/04 navelbine, herceptin, aredia
2/05 herceptin/aredia
7/05 xeloda/herceptin/aredia
3/07 xeloda/tykerb/aredia
5/08 taxol/avastin/aredia
2/09 gemzar/herceptin/zometa
7/09 Taxol/Carbo/Herceptin, zometa
10/09 navelbine/herceptin & zometa
2/10 herceptin & tykerb & zometa
4/10 add xeloda &aromasin
10/10 dx with dermatomyiositis triggered by cancer
11/10 restart herceptin, tykerb, zometa
12/10 surgery-place rod in R femur to stabilize bone
1/11 radiation to R femur - 20 tx
2/11 2nd surgery - rod in Left femur
2/11 tx eribulen -- suspended dx brain mets
3/11 brain mets wbr 20 tx
4/11 halaven; discontine 8/11 not working
8/11 radiation to left femur 20 tx'
8-9/11 rad to lower spine
9/11 abraxane/herceptin/zometa
9/12 xeloda/herceptin/zometa
12/12 ablation of liver
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05-26-2010, 07:07 AM
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#3
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Re: navelbine/herceptin
Hi Sally!
I found Navelbine and Herceptin very doable after the others!
Side effects were mild. ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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05-26-2010, 07:23 AM
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#4
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Senior Member
Join Date: Jul 2006
Posts: 869
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Re: navelbine/herceptin
ditto for me...I was on it for about 18 months...hair thinned a bit but I was also on Xeloda, too. Good Luck
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06-02-2010, 09:20 PM
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#5
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Senior Member
Join Date: May 2006
Posts: 157
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Re: navelbine/herceptin
Sally,
I was on Nalvabine/Herceptin for 18 months (2006/2007), and the combo almost made the tumors in my lung disappear. It was a very easy combo, my hair grew back, I felt normal, just had low wbc sometimes, so I had to get neupogen shots or to skip chemo, but it was very doable. Nalvabine was the best chemo for me so far, I hope it will be for you too.
KarlaV.
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06-03-2010, 02:40 PM
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#6
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Senior Member
Join Date: Jul 2009
Location: Sardegna, Italy
Posts: 362
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Re: navelbine/herceptin
Sally - I chose the combination when I first did my therapy (See my signature) but they have had good results with N and H - that is why I chose it. And... it isn't that "toxic" of a chemo. Also --- I would HIGHLY suggest taking it in pill form --- I started with the IV fluid form and then after 3 weeks one of the nurses set the IV too slow and the chemo burned up my left arms veins --- so we went to weekly pills as I needed some time off for my veins to heal. The bright side of that was that the pills seemed to make me less sick and less tired. Not sure why - but my body handled it WAY better. I would try the pills if I were you!
:-) Also - along with the drugs - I would highly suggest you read this book:
Beating Cancer with Nutrition. By Patrick Quillen PhD
He writes about how to combine chemo and therapy with nutrition and how to protect our bodies from more damage - he has great references to what types of supplements to take (or not take) when doing therapy --- as he worked with a cancer hospital and had lots of great success stories with cancer. I am reading his book now and wished I would have known what I am learning now --- back last year when I was doing the treatment!
Feel free to email me if you have more questions - "wheelistic@yahoo.com" ---
Take care - Karen
__________________
Karen Wheelhouse Age: 46
Facebook id: Karen Wheel
2-09 – Age 44 -Biopsy-Cancer
3-09 – Right Quadrantectomy. Clear margins.
3 lymph nodes taken - all clear
Tumor results: Stage 1, 1.5 cm, Her2 +++
Est positive 80% - Prog 10% - Ki67 postive 30%
4-09 – Became a vegan! pH balance of body - cancer can't grow in neutral pH!
4-09 Started Herceptin & Chemo (9 weeks of Navelbine *)
* FYI - when coupled with Herceptin has the same results as more toxic chemo. No brainer!
8-09 - 30 RADS
9-09 - Said NO to hormone therapy
4-10 Finished Herceptin!!!!
7-10 PET Scan & other exams .... All clear! YIPPEE!!!!
11-10 Breast, organ Ultrasounds and lung x-rays all clear no changes ... NED!
2-25-2011 --- 2 years from surgery and NED!!!!!!
7-2011 Clear bone scan and full body and head MRI! NED! NED! NED! ;-)[/SIZE]
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06-04-2010, 12:41 AM
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#7
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: navelbine/herceptin
Hi Sally,
Navelbine and Herceptin have a good synergy--and best of all it's very easily tolerated by most. I did it for five months and went on with my daily life with little to no problems. Slight hair thinning and the worse thing would be low wbc. I gave myself Neupogen shots for that. But no heavy side affects...life was pretty good on that combo. Wishing you all the best...lets us know how it goes. Here's to it kicking cancers butt.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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06-06-2010, 07:53 PM
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#8
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Senior Member
Join Date: Oct 2005
Location: Saratoga Springs New York
Posts: 136
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Re: navelbine/herceptin
I would like to thank everyone for their time and sharing their experiences with me. I start Herceptin/Navelbine tomorrow. I will let you know how I make out. Thanks again, Sally
__________________
Dx March 2004 HER2+ er/pr+ 8/16 + lymphnodes mets to the liver Stage IV / 6 cycles of TCH and 33 rads . NED Continued Herceptin 3 years w/ Femara. Tumor markers start to rise in Jan of 2007 and swiched to Tamoxifen. August of 2007 found more mets to liver and lymphnodes outside of liver. Went on Tykerb/Xeleoda--spots on liver gone found large mass between intestines. March 2008 started TCH. Stopped Carboplatin due to allergy. Still on Taxotere and Herceptin. Nov 2008 mass is gone. 3 new spot on liver and one on spine. Radiation on spine. tykerb/gemzar for liver mets. PET in April 09 showed shrinkage still a little activity, continue tykerb/gemzar until Aug 09. PET showed new spot on my spine more on my liver and a bunch of enlarged lymphnodes in upper chest. Start Adriamycin Sep 09. more radiation on spine . April 2010- Still on Adriamycin 3wks on 1 wk off and zometa every 28 days. PET -May 2010 showed progression. Starting Herceptin/Navelbine on June '10
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06-12-2010, 05:35 AM
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#9
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Re: navelbine/herceptin
Sally
Hoping this combo is very easy on you...it was one of my easiest...wish it worked longer for me....hope it is doing its job!!!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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