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04-26-2007, 09:17 AM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,783
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quality of life in 2-5 yr cancer survivors
fatigue is the big factor in 41% --pain, cognitive problems, inactivity, weight gain, antidepressant use associated. If inertia could be overcome, might exercise help many/most of these? Pool therapy? Just thinking out loud!
1: Qual Life Res. 2007 Apr 25; [Epub ahead of print]
Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report.
Meeske K,
Smith AW,
Alfano CM,
McGregor BA,
McTiernan A,
Baumgartner KB,
Malone KE,
Reeve BB,
Ballard-Barbash R,
Bernstein L.
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, USC/Norris Comprehensive Cancer Center, 1444 Eastlake Avenue, Room 4449, Los Angeles, CA, 90033, USA, lbern@usc.edu.
Purpose The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors. Methods Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms. Results Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning. Conclusion This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.
PMID: 17457697 [PubMed - as supplied by publisher]
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04-26-2007, 10:25 AM
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#2
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Senior Member
Join Date: Sep 2005
Location: Ohio
Posts: 212
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Thanks for posting this, Lani. I'm printing it out to show my husband why I still often need to take a nap during the day, even though my last treatment was several years ago. Exercise does help the energy level, looking forward to getting outside more now that the weather is nice.
__________________
Audrey
diagnosed July 2001, at age 36
large tumor, 11+ nodes
Stage IIIb, er/pr-, Her2+
treated with A/C, weekly Taxol
radiation, + year of Herceptin
on clinical trial. double mastectomy
followed by reconstruction
NED!!
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04-26-2007, 10:56 AM
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#3
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Does this mean I should get the in ground pool I've been wanting? I can feel the sun already!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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04-26-2007, 02:06 PM
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#4
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Member
Join Date: Feb 2006
Posts: 6
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Thank you for that Lani. Makes me feel better. I am nearly 2 years post diagnosis and still seem to get fatigue. I go a few days feeling OK and then it hits again, with headaches, backaches and awful tiredness. Nice to know it is pretty normal. I only finished herceptin a couple of months ago and was very tired on that, so I suppose it takes a while to get over it all.
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04-26-2007, 03:03 PM
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#5
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Oh, my! And I was going to settle for a piece of exercise equipment!!!!!!
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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04-28-2007, 03:25 PM
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#6
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Senior Member
Join Date: Nov 2006
Location: London, England
Posts: 96
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Half relieved, half "Oh no!"
Lani,
Thanks again for an interesting post. I finished radiotherapy in February, after a year of surgery, chemo and general body battering, and was beginning to feel better and better by the day. Last week I had a run of a few days of feeling completely wiped out, and there I was, only a year after diagnosis, thinking "Surely I should be feeling more energetic by now?"!
I'm feeling a a funny mixture of relief and "3-5 YEARS??*! Noooo!"
I too will print this one off, as a reminder to myself and others that this could go on for a while...
__________________
Caroline
Diag. March 10th 2006, aged 46.
Invasive ductal carcinoma, 2cm + multifocal. Stage 2, Grade 3
HER2+++, ER+/PR+
Right mast. May 2006. 6 of 20 nodes positive
FEC x 4, taxotere x 4; port implanted after 6 cycles
Rads x 25
1 year of Herceptin ended Nov 07.
Arimidex 5 years
Considering reconstruction, maybe soon...
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