 |
03-06-2007, 10:55 PM
|
#1
|
|
Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
|
For Lani ...what research is there on PTEN
Do we know for certain what role PTEN alteration plays in her2 tumors?
We know there is a connection however I thought it is
still tangential. I thought that PTEN was under research at MD Anderson.
Is there any good drug to target the PI-3 Kinase/PTEN pathway
for those that test negative for PTEN? I don't believe there is any 
Thanks Lani,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
|
|
|
|
03-06-2007, 11:51 PM
|
#2
|
|
Senior Member
Join Date: Mar 2006
Posts: 4,780
|
sorry Jean
you've got me on a bad day...I am travelling with limited internet access. Will try to answer this weekend.
Lani
|
|
|
|
|
03-07-2007, 01:31 AM
|
#3
|
|
Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
|
thx Lani
Safe return....
Regards,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
|
|
|
|
|
03-11-2007, 10:15 AM
|
#4
|
|
Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
|
Lani...
Just moving this up.....Lani know how busy you are and welcome back from
your business trips - always good to get home...after one of those.
If you have or can find anything on this I would apprecite. I have
looked around but did not find anything.
Kind Regards,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
|
|
|
|
|
03-11-2007, 03:18 PM
|
#6
|
|
Senior Member
Join Date: Mar 2006
Posts: 4,780
|
Jean , you're welcome... but someone else needs YOUR help
hit by stomach flu upon my return.
A few brief thoughts...I posted already how Tykerb's efficacy doesn't depend on the presence of PTEN and therefore should work on those with her2+ tumors who are not PTEN positive.
Will try to add more later...
|
|
|
|
|
03-11-2007, 04:47 PM
|
#7
|
|
Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
|
Ugh.....
Hoping you feel better fast....yes, I am already in contact!
You can now add mind reader to propeller head....
Sending healing energy.
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
|
|
|
|
|
03-11-2007, 05:00 PM
|
#8
|
|
Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
|
Heblajo1....good reading....
Many thanks,
I was anxious to know if any new class of drugs have been noted (besides
the natural food track) to increase the level of PTEN....or if any drugs being
tested have shown some hope?
Good links and enjoyed reading....
Regards,
jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
|
|
|
|
Posting Rules
|
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
HTML code is Off
|
|
|
All times are GMT -7. The time now is 03:32 PM.
|
Hybrid Mode