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01-20-2014, 06:51 AM
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#1
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Senior Member
Join Date: Aug 2011
Posts: 51
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Faslodex and castor oil concerns
My mother has stage iv metastIc breast cancer. Her cancer is hormone positive and her2 positive. She has gone through aromatase inhibitor and she is currently taking tamoxifen. Whe tamoxifen stops working she may go on faslodex. But i'm concerned about the castor oil in it. Two years ago she did taxol, and she got a severe Allergic reaction to the castor oil in it. Is there a chance that she can get the faslodex? Is the intramuscolar route different than the iv route? Is there someone Who was allergic to taxol but managed to get faslodex anyway?
Thanks for your answers.
__________________
Son of Ha
She has been dignosed in February 2008 BC state IV, left breast multiple nodes size 5 cm, mets lungs and liver. Er+ Pr+ Her neu +++.
3/2008 - 10/2010 Herceptin + Aramidex NED
10/2010 recurrence lung met, pleural effusion, toracentesis
11/2010- Tyverb + Navalbine NED
08/2011 CA-15-3 = 90 scan
08/2011 Scan revealed reccurrence lung met, tiny metastasis on the pleura and pleural effusion.
4 pills tyverb, mytoxantrone once ever three weeks, and Aromasin.
Tykerb and taxol, sever allergic reaction
Tykerb taxotere
Herceptin, perjeta, gemcitabina
C- diff, bad diarrea
Halevan and tamoxifen, tm down from 1200 to 130
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01-20-2014, 01:22 PM
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#2
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Re: Faslodex and castor oil concerns
It is not the castor oil but a castor oil ethoxylate in Taxol that makes one allergic so make sure Faslodex has castor oil ethoxylate. Castor Oil ethoxylate is a surfactant that makes oil and water mix into a homogenous solution. I know about it well because, believe it or not, I used to sell it to Bristol Myers back in the day. It is a common personal care emulsifier but it was super highly refined for Taxol and therefore quite expensive. I actually had troubles with Taxol because of it and told my onc, "I knew my company would kill me one way or another". He did not laugh but I did.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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01-21-2014, 02:30 AM
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#3
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Senior Member
Join Date: Aug 2011
Posts: 51
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Re: Faslodex and castor oil concerns
thanks for the reply Becky,
you are right, the issue with taxol is the cremophor, and not the castor oil. I thought they were the same thing, instead they are not. I checked out, and faslodex contains castor oil, and not cremophor.
I'm less concerned now, thanks for clarifying.
Best regards
__________________
Son of Ha
She has been dignosed in February 2008 BC state IV, left breast multiple nodes size 5 cm, mets lungs and liver. Er+ Pr+ Her neu +++.
3/2008 - 10/2010 Herceptin + Aramidex NED
10/2010 recurrence lung met, pleural effusion, toracentesis
11/2010- Tyverb + Navalbine NED
08/2011 CA-15-3 = 90 scan
08/2011 Scan revealed reccurrence lung met, tiny metastasis on the pleura and pleural effusion.
4 pills tyverb, mytoxantrone once ever three weeks, and Aromasin.
Tykerb and taxol, sever allergic reaction
Tykerb taxotere
Herceptin, perjeta, gemcitabina
C- diff, bad diarrea
Halevan and tamoxifen, tm down from 1200 to 130
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01-21-2014, 08:14 AM
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#4
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Senior Member
Join Date: Jun 2011
Location: Iowa
Posts: 231
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Re: Faslodex and castor oil concerns
I know nothing about the ingredients in faslodex but I can tell you a lot about being on it. It is a huge pain in the ass, literally. It is two huge injections of 5 ml each, one into each butt cheek. It hurts a lot, worse than any IV I have had. But it is fleeting and once the needle is out, it's not too bad. After a few months the butt does adjust and you get accustomed to having a higher level of inflammation in the muscle there, but things like jogging don't feel all that great at first. Best way to handle the soreness and inflammation is actually using the muscle and breaking up any scar tissue that may want to develop. The other thing that helps is heat packs right after injection. I was only on it for a few months before I progressed, and it actually took another 4 months for my butt tenderness to go back to normal. Don't get me wrong, it is a great drug, just want you to have all the info.
Kristin
__________________
[B]Kristin
Aug 2010: diagnosed stage 3b, 4 mo. after birth of son. 29 yrs old and breastfeeding, ER/PR-, Her-2+ started Neoadjuvant therapy: 4x FEC, 10x abraxane & Herceptin
Feb 2011: L mx with recon. Path. showed only DCIS but 4/10+ nodes.
March 2011: 6 wks rads.
Mother passed, lower back pain.
Late May 2011: Bone mets but organs clear; Tykerb, Xeloda, Xgeva. Stopped Herceptin. Implant infected: removed implant.
October 2011: Bone progression; Gemzar and Carboplatin & restarted Herceptin.
Jan 2012: Progression, re-classified as ER+; Tykerb, Herceptin, Zoladex & Femara. Anti-E is working!
May 2012: ovaries out, markers stable but elevated. Cont. Herceptin, Tykerb, Xgeva & Femara.
Dec 2012: aromasin
Jan 2013: faslodex, herceptin, tykerb
Jun: Kadcyla
Aug: Rads to hip, then Perjeta, Herceptin & Taxotere
Nov 2013: Perjeta, Herceptin, Halaven
Early 2014: Affinitor, Aromasin, Perjeta, Herceptin.
June 2014: Estradiol, Perjeta, Herceptin
Aug 14: Tamoxofin, H & P
http://kristin-notdying-blog.blogspot.com/
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