Re: No Equivalence for Paclitaxel vs Doxorubicin/Cyclophosphamide
I stumbled on this looking for the results of the 4 vs 6 question, and posted it as a reminder to myself to go back and read the study details.
Interesting conclusions. I think the title is a bit dramatic for the information. A 1% overall survival benefit, and 9 treatment deaths in the doxorubicin/cyclophosphamide arm.
I think adjuvant TCH was a good treatment choice for the time, and ACTH for its time. With pCR, I see the industry shifting toward TCHP which has the highest pCR, and a move to subtyping research.
What was not obvious was the data on the 4 vs 6 treatments. It was mentioned that the enrollment in the 6 treatment arm slowed in accrual and was dropped in 2008.
Are the numbers above based on 4 treatments? If so it looks quite similar to the 6 treatment numbers of DFS and OS.
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