I need advice on chemo treatment

[diannel]

Hi All:
I joined last night.
I am 59. Right breast lumpectomy: IDC removed 7/29/04. 1 cm. ER+ 60% and PR+30%. HER 2 neg by FISH. Node negative. Radiationx33. On Arimidex since Nov. 04.
NOW left breast lumpectomy: IDC removed 5/24/07 2 cm. Er+70% PR neg. Her2 positive: FISH signal ratio 6.49. Node negative. They say it is a new primary tumor.
I also have a 2.2 cm tumor on my R kidney. I was supposed to have surgery today, but developed bronchitis with a nasty cough, surgery is post-poned to early July; they say that is a new primary tumor too. I asked them to go back to a 2004 CT scan, and it was there then, supposed to be a slow-grower, only .3 to.4 mm a year.
Ater I get the kidney surgery, at which time they are just removing the tumor and 1 mm margins, my oncologist wants to start me on either:
1. AC 4@ 3 wk intervals. then TH 3@1 wk intervals. then H for 9 months for a total of 15 months treatment. OR
2. TCH 6@ 3 wk intervals. then H for 34 weeks, I don't know at what intervals, for a total of 12 months treatment.
My questions are: (Please give me your reasons in your answer)
1. Which chemo should I have?
2. Is it going to be hard for my kidney to heal if I start chemo 2-3 weeks after surgery?
3. Is there some gene assay test out there to determine if my HER2 is going to respond to this therapy?
4. Should I get the Oncotype DX assay? (I think it gives you a recurrence score, but only based on Er status, not Her2 status.)
5. Am I waiting too long to start chemo if I start it the third or fourth week of July? Should I start chemo before kidney surgery?
6. Has anyone had anything similar like this?
I would really appreciate any advice.
Thanks,
Dianne L

[julierene]

Being HER2 positive, I would want the 2nd treatment. I have had both treatments, and the TCH was much more tolerable, did a super job, and I didn't loose my hair on that one. But that is just me.

[Erin]

I am doing option #2 now. If you google UCLA, Jonsson Cancer Center (sp), and Herceptin you will probably find the study that was recently completed at UCLA which rates the TCH just as effective as the AC, with less chance for cardio toxicity. You may be able to find the old thread on this site as well. Best of luck with all your decisions, there are many, but the women on this site will be a great source of info for you.

[MJo]

Hang in there.

Oncotype -- If your insurance doesn't cover the Oncotype, you will have a bill for about $3400. Her2 is one of the things the Oncotype takes into account, according to my Onc, which is why Her2+ Oncotype scores are usually high. The last time I looked at the Johns Hopkins Ask an Expert site (if you haven't checked it out, take a look) they werent recommending the Oncotype for Her2 positives because they felt scores for majority of Her2s would show high risk anyway.

I took the AC in 2006 and had a bad time. Possibly, AC contributed to my having to stop Herceptin after 9 months due to cardio problems. If the Johnson Study says TCH is just as effective, I know which one I would choose.

I finished my treatment, except for arimidex, so I haven't been paying attention to discussion about new tests. But I know some women on this site are very knowlegable. They likely will respond to your questions

I don't know if your kidney is at risk during chemo due to surgery. I think your doctors need to reassure you about this. You could also try talking to the nurses. Should you start chemo before kidney surgery? I think doctors don't like to do surgery on chemo patients due to blood thinning issues. But again, your doctors need to explain this.

Are you waiting too long? I think two months is pushing the limits, but a friend of mine waited 7 weeks to start chemo after lumpectomy because she didn't want chemo during Christmas and New Year holidays. Oncologist didn't seem worried. Her BC profile was similar to yours. Plus you have to think about your whole body due to bronchitis and kidney issues.

All the very best to you. The next few months won't be a picnic, but I look forward to hearing good things from you in the future.

[Lala]

Dianne
Sorry to hear about your surgery. Ask your Urologist about the roll of chemotherapy after surgery. I would recover first then worry about doing chemotherapy later.

As far as your choice in 2 different lines of chemotherapy;
I would do the TCH as it is shown to be safer than AC. There is much information out there on the TCH combination. The Adriamycin is more cardio toxic than other chemotherapys. I have posted some web links for you to see the role of these drugs. Also a link about the Topo II test; this is a test where you send off tumor to see if it would respond to Adriamycin.

Here is a web link that show TCH outperformed AC and TH.
http://www.oncology-times.com/pt/re/...856145!8091!-1

Here is web link to an article that talks about the test called TOPO II
If you have TOPO II amplification you are likely to respond to Adriamycin.
http://www.aaci-cancer.org/n_detail....pid=39&sid=200

I wish you the best of Luck.

[chrisy]

Wow, you are quite a veteran. I can tell you're a fighter!

I'll give you my 2 cents (which is worth probably way less than that!) but, maybe could you clarify something for me. You say they are calling the kidney tumor a new primary? So is it a kidney cancer not a metastasis from the breast cancer? That may impact the treatment decisions if you are trying to do adjuvant chemo for a kidney lesion - although many of the treatments for renal cell cancers are the same as for bc.

I agree with what the others have said re the A/C and the cardiac toxicity. The risk of this with Herceptin after A/C is higher than if you did not have the A/C. And not to throw yet another wrinkle in, but have you considered T/H weekly instead of every 3 weeks? This uses a lower dose, and is supposed to be better tolerated and just as effective.

It sounds like you would also consider continuing the hormonal treatment, if this is a new primary and still er+

[diannel]

Hi Chrisy:

Thanks for the response. Yes, they are saying the kidney tumor is a new primary, and that it has been there at least since 2004, but I guess I will know for sure when the pathology comes back on it, after surgery.
My oncologist said he might switch me to Tamoxifen, since the Arimidex didn't seem to work. This new breast tumor was 70% ER positve, PR neg. and Her 2 positive. Whereas the one from three years ago on the other breast was 60% ER positive and 30% PR positive and Her 2 negative.
Thanks,
Dianne L

[diannel]

Hi Lala:

Thanks so much for the two articles. It still sounds like reduction for risk of recurrence is better by 12% for the Adriamycin group. I guess I have to find out if I am Topo II positive. Does anyone know anything about the test or where to get it?
Thanks,
DianneL

[Lala]

Dianne
I am confused as to where the 12% recurrence rate is stated in which article?

I just looked at the article
Breast Cancer: Non-Anthracycline Regimens Superior for Early Her2 Positive Disease once again.

It states that
Both of the trastuzumab-containing regimens significantly improved disease-free survival compared with the non-trastuzumab-containing regimens; at four years, 92% of patients on ACTH and 91% of patients on TCH were still alive compared with 86% in the AC→T arm.

TCH outperformed AC→T and AC→TH in the treatment of breast cancer, Dr. Slamon said.

TCH had the optimal therapeutic index, thus avoiding the cardiac damage related to sequential use of anthracyclines and trastuzumab.

The best outcome for early-stage HER2-positive breast cancer is obtained with a non-anthracycline regimen [TCH], and results of this trial should impact the way early-stage breast cancer is treated. TCH should be the preferred option in HER2-positive early breast cancer. He questioned whether there is still a role for anthracyclines in the treatment of early breast cancer.

Because Anthracyclines are cardio toxic there is a higher risk for those who take herceptin.

I still think TCH is the better combination overall.
Also in regards to tamoxifen I tried it but found it did not work for me. I was told that Fasoldex would be better as there are studies showing it works in mets. I too am pre meno so I would have to use this with a Lupron shot. Maybe you should ask your oncologist for the studies showing tamoxifen vs fasoldex. It takes 3 months for hormone drugs to show response vs chemotherapy that takes 2 months. There are so many treatment options available.

I wish you the best.

[Patricia]

Hi Dianne,

I had 2 primaries at the same time (breast and thyroid) and had my surgeries about 6 weeks apart. I did not start my chemo for another 3 weeks as the dr's wanted the time to allow my body to recover from the surgeries. The way my dr's decided was that they felt it was better to get the cancers out and take the risk of starting the chemo a little later as a result. It was something that I personally was nervous about. I was very happy once I started the chemo because it was beyond the amount of time that in general they recommend waiting. They did start me on Lupron (which I am still on until I have an oopherectomy) before chemo though to at least get my hormones shut down asap. I can't speak to your specific situation, but I think it is important to weigh the risk of which is worse to delay.

In terms of your drug options, I don't feel educated enough to advise you. I did have the 1st option AC x4DD then 11 T&H followed by 9 mos of Herceptin. I had a very hard time with the AC&T due to side effects.

I was told by my onc that there was no need to do the oncotype since I was Her2+ (100%).

Welcome to the board, this is a wonderful site with the most educated caring women. I am sure that others will have words of advice for you.

Hugs,
Patricia