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09-30-2010, 07:47 PM
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#1
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Member
Join Date: Jun 2009
Posts: 20
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lung mets
My daughter in law developed lung mets that were seen 9/29. She started a trial that involved insulin receptors, in the beginning of August. Lung tumors were not observed then. She has had bone involvement for two years and was on Xyloda/Tykerb during this time. This is the first spread into soft tissue.
Her oncologist will get back to her in a week.
I would appreciate thoughts about prognosis, treatment options, anything that comes to mind.
Thanks
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09-30-2010, 09:08 PM
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#2
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Senior Member
Join Date: Jun 2009
Location: Los Angeles, CA
Posts: 309
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Re: lung mets
Hi Rob-
I am unable to help out with this one, but is that correct that
your daughter in law developed lung mets yesterday? if not what year? you didnt indicate what year? I was a bit confused reading this=but nothing new there-I am confused a lot---
Good Luck!!!!
__________________
DX: 11/08 Age: 53
Surgery: 1/09
Bilat Mastectomy, no reconstruction
ILC-4 tumors-1.7 cm,1.5 cm (2).8 cm
DCIS-11 cm
All tumors Grade 3
All tumors ER-0%/PR-0%
All tumors HER2+
IHC-all tumors Overexpression/borderline
FISH 2 tumors Her2-Negative
FISH 2 tumors Her2+ Equivocal
Stage I, 0/1 nodes
LVI-Indeterminate(treated as positive)
SPR Score 8/9
Ki-67 20%
BRCA genetic test 1/2=negative
Chemo: 6 rounds TAC Feb-June 2009 w/Neulasta
Herceptin: 6/12/09-6/4/10 52weeks
HNPCC genetic test: negative
Port Placement-9/23/09 Port Removal 6/25/10
Echo's every 3 months-All normal
2/09 Staging PET/CT showed 0.2 micronodule upper R lobe-lung-Onc does not think this is mets--
6/5/09 AND 10/09 CT scan 0.2 micronodule unchanged
1/10-PET/CT-uptake in nasopharynx-
1/10-MRI All normal
6/10-Bone Scan-clear
12/10-PET/CT-All Clear-NED
12/11-PET-All Clear-NED
12/12-PET-All Clear-NED
12/13-CT w/contrast Head, Torso-All Clear
12/14-CT w/contrast Head-All Clear
2/15-Core needle biopsy-R scar line
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09-30-2010, 10:42 PM
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#3
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
Hi Cal-Gal, thanks for the reply.
The mets were visible on the CAT scan taken yesterday. A scan taken in the beginning of August showed none, so the tumors have been growing over the last two months.
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09-30-2010, 11:02 PM
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#4
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: lung mets
Both lungs? How many and how large?
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10-01-2010, 11:55 AM
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#5
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
Rich66
Multiple 6-8mm sites [number ?], in both lungs.
Rob
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10-01-2010, 04:39 PM
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#6
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Senior Member
Join Date: Aug 2008
Location: San Francisco
Posts: 260
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Re: lung mets
Hi Rob - I have had two bouts of lung mets, both successfully cleared up with various chemos. The first occurrence was at the time of my initial diagnosis. As you can see from my signature, I was initially put on Cytoxan, Taxotere and Herceptin. The lung mets came back last fall and I was treated with Gemzar/Herceptin. Fingers crossed that they don't come back again.
Know that your daughter-in-law has many treatment options available. Next up in my chemo arsenal should I need it is Navelbine. I'd have your DIL ask about these chemos as possible systemic treatments. Radiation may also be an option.
__________________
4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.
Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial
Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED
Send me a PM if you'd like to follow my journey on Caringbridge.
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10-01-2010, 06:43 PM
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#7
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
Hi CourtneyL
Thanks for the encouraging information. DIL will follow through.
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10-01-2010, 08:47 PM
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#8
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: lung mets
I asked because I recently learned that interventional radiologists consider lesions under 3cm the best candidates for "local" therapies like RFA, cryotherapy etc. So..you probably have leeway to try dealing with them through systemic chemo..just figured it's good to know if/when a lesion is bumping up against a size limit. Had I been aware of this issue, would have been more persistent in pursuing local therapies earlier. I get the sense oncs naturally tend to think more in terms of the tools they have more training in...i.e. chemo
Joan has direct knowledge of local treatments of lung mets and will likely opine.
I have placed some lung met info HERE
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10-02-2010, 05:04 PM
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#9
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
Thanks Rich66
Will pursue this with onc this week.
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10-02-2010, 09:09 PM
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#10
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Senior Member
Join Date: Feb 2006
Posts: 1,014
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Re: lung mets
I was diagnosed in Dec 05 with 2 small lung mets. I did 4 months of Taxotere, Xeloda, and Herceptin..I took the herceptin in conjunction with the other two. I had a complete response to the chemo and have been cancer free since then. I was given a 19 percent 5 year survival rate and here I am. In December it will be 5 years and I feel great. I do remain on Herceptin indefinately and I have PET/CT scans every 6 months.
sherryg
__________________
Sherry
Diagnosed: December , 2005 at age 44
13+ positive lymph nodes
Stage IV , Her2+, 2 small mets to lungsChemo Started: Jan, 2006
4 months Taxotere, Xeloda, Hercepin
NED since April 2006!!
36 Rads to follow with weekly Herceptin indefinately
8 years NED now
Scans every year
Life is not about avoiding the thunderstorms, it's about learning to dance in the rain!
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10-03-2010, 09:28 AM
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#11
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
Sherryg683
Thanks, you brought a smile to my face.
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10-04-2010, 02:15 AM
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#12
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: lung mets
Rob,
We have another Her2 sister on this board "mamacze" (Kim). She may drop in and chime in? She had mets to four lobes of her lungs & liver in 2004...she did Navelbine/Herceptin combo and had been NED (no evidence of disease) since. She has just maintained on Herceptin alone. This might be a good time to set-up a 2nd opinion so you hear other options. Keep us updated.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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10-05-2010, 10:41 AM
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#13
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
Thanks Cheelee
Will keep you updated.
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10-14-2010, 10:46 AM
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#14
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Member
Join Date: Jun 2009
Posts: 20
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Re: lung mets
DIL will start navelbine/herceptin treatment in a few days. There is a question as to whether Canada will pay for a second round of herceptin.
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10-14-2010, 10:38 PM
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#15
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,809
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Re: lung mets
There are several members who are also residents of Canada. If you look at the signatures of long-time survivors, you will see many have been on Herceptin either continuously or whenever there's a recurrence.
I hope everything works out well for your daughter-in-law.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
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