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09-14-2006, 07:54 PM
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#1
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Senior Member
Join Date: Jul 2006
Posts: 869
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Breast Cancer Vaccine...How? What? When?
Please someone explain to me about the breast cancer vaccine-is this for her2 only? How do you get one? Is this experimental? How long is it good for? Can you get one before NED-my oncologist has never mentioned this. Thanks Ceesun
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09-14-2006, 08:23 PM
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#2
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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Here's a link to a post I made on the "Clinical Trials" page, which will in turn provide you with some links to a few papers published on the Her2 vaccines; these may help answer some of your questions. The breast cancer vaccines are indeed experimental at this point, one must "qualify" and enroll in a clinical trial to receive a particular vaccine.
http://www.her2support.org/vbulletin...ad.php?t=24105
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09-14-2006, 08:39 PM
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#3
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Senior Member
Join Date: Dec 2005
Location: Illinois
Posts: 327
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I was just told by UW that my MUGA didn't qualify or something. I was 45% in August 2--6. The last one they did was like Feb. 2004 - which was 50%. Any light on this?
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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09-15-2006, 05:36 PM
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#4
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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Julie, I think your baseline MUGA of 50% is considered borderline normal, and 45% is definitely low. One of the unknowns of the vaccine is how it will affect heart function since cells in the heart muscle have Her2 receptors. Therefore, to qualify for the study your starting MUGA has to be at least 50%, from my understanding.
Sorry you didn't qualify for this vaccine, I know it must be dissapointing.
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09-18-2006, 08:45 PM
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#5
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Senior Member
Join Date: Dec 2005
Location: Illinois
Posts: 327
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Any ideas on how to increase my MUGA 5% in 3 weeks?!
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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09-18-2006, 10:20 PM
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#6
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Senior Member
Join Date: Sep 2005
Location: Vancouver, Canada
Posts: 329
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Don't worry, I talked to the Nurse at UW and she said the trial won't start until December. Have you stopped Herceptin, it seems when the test shows less then 50%, they stop Herceptin.
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